AC Milan boss Stefano Pioli will be forced into changes to his starting XI compared to the team that drew with Parma on Sunday.
Pioli will be without the injured quartet Kjaer, Gabbia, Bennacer and Ibrahimovic, with Gabbia and Bennacer almost certain to miss the rest of the year, while Kjaer and Ibra are close to a return.
In goal will be Gianluigi Donnarumma, supported by a back four of Davide Calabria, Pierre Kalulu, Alessio Romagnoli and Theo Hernandez from right to left.
Sandro Tonali will start alongside the irreplaceable Franck Kessie in midfield, who will have to be very careful since he is one booking away from a suspension.
Ante Rebic will once again be the centre-forward and it seems as though Rafael Leao has won the battle for the left wing spot over Jens Petter Hauge. Hakan Calhanoglu and Samu Castillejo will complete the trident, as Saelemaekers has not yet fully recovered.
Probable Milan XI (4-2-3-1): Donnarumma; Calabria, Kalulu, Romagnoli, Theo Hernandez; Kessie, Tonali; Castillejo, Calhanoglu, Leao; Rebic.